Flack, C and J. S. Parkinson (2022) Structural signatures of Escherichia coli chemoreceptor signaling states revealed by cellular crosslinking. Proc Natl Acad Sci USA Jul 12;119(28), Link
Piñas G.E., DeSantis M.D., Cassidy C.K. and J.S. Parkinson (2022) Hexameric rings of the scaffolding protein CheW enhance response sensitivity and cooperativity in Escherichia coli chemoreceptor arrays. Sci. Signal., 15: DOI: 10.1126/scisignal.abj1737. Link
Burt A., Cassidy C.K., Ames, P., Bacla-Verloop M., Baulard M., Huard K., Luthey-Schulten Z., Desfosses A., Stansfield P.J., Margolin W., Parkinson J.S. & I. Gutsche (2020) Complete structure of the core signalling unit of the E. coli chemosensory array in an optimised minicell strain. Nature Communications, 11:743 doi.org/10.1038/s41467-020-14350-9. PDF
Cassidy C.K., Himes B.A., Sun D., Ma J., Zhao G., Parkinson J.S. Stansfield P.J. Luthey-Schulten Z. & P. Zhang (2020) Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations. Nature Commun. Biology, 3: 24 doi:10.1038/s42003-019-0748-0. PDF
Piñas G.E. & J.S. Parkinson (2019) Identification of a kinase-active CheA conformation in Escherichia coli chemoreceptor signaling complexes. J Bacteriol. 201:e00543-19 doi:10.1128/JB.00543-19. PDF
Gao, Q., A. Cheng & J.S. Parkinson (2019) Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli. Proc. Natl. Acad. Sci. USA, 116:15651-15660. doi: 10.1073/pnas.1902521116. PDF
Yang, W., C.K. Cassidy, P. Ames, C.A. Diebolder, K. Schulten, Z. Luthey-Schulten, J.S. Parkinson & A. Briegel (2019) In situ conformational changes of the Escherichia coli serine chemoreceptor in different signaling states. mBio, 10:e00973-19. doi: 10.1128/mBio.00973-19. PDF
Piñas, G.E., DeSantis, M.D. & J.S. Parkinson (2018) Noncritical signaling role of a kinase-receptor interaction surface in the Escherichia coli chemosensory core complex. J. Mol. Biol., 430:1051-1064. PDF
Flack, C.E. & J.S. Parkinson (2018) A zipped-helix cap potentiates HAMP domain control of chemoreceptor signaling. Proc. Natl. Acad. Sci. USA, 115:E3519-E3528. doi: 10.1073/pnas.1721554115]. PDF
Lai, R.Z., Han, X.S., Dahlquist, F.W. & J.S. Parkinson (2017) Paradoxical enhancement of chemoreceptor detection sensitivity by a sensory adaptation enzyme. Proc. Natl. Acad. Sci. USA, 114:E7583-E7591. doi: 10.1073/pnas.1709075114. PDF
Lai, R.Z., K.K. Gosink & J.S. Parkinson (2017) Signaling consequences of structural lesions that alter the stability of chemoreceptor trimers of dimers. J. Mol. Biol. 429: 823-835. PDF
Frank V., G.E. Piñas, H. Cohen., J.S. Parkinson & A. Vaknin (2016) Networked chemoreceptors benefit bacterial chemotaxis performance. mBio 7:6. doi:10.1128/mBio.01824-16. PDF
Ames, P., S. Hunter, J.S. Parkinson (2016) Evidence for a Helix-Clutch Mechanism of Transmembrane Signaling in a Bacterial Chemoreceptor. J Mol Biol 428, 3776–3788 PDF
Piñas, G. E., V. Frank, A. Vaknin, and J.S. Parkinson (2016) The source of high signal cooperativity in bacterial
chemosensory arrays. PNAS 113: 3335–3340 PDF
Mowery, P., P. Ames, R.H. Reiser, J.S. Parkinson (2015) Chemotactic Signaling by Single-Chain Chemoreceptors. PLOS ONE DOI:10.1371/journal.pone.0145267 PDF
Kitanovic, S., P. Ames and J.S. Parkinson (2015) A trigger residue for transmembrane signaling in the Escherichia coli serine chemoreceptor. J. Bacteriol. 197: 2568-2579. PDF
Lai, R.Z. and J.S. Parkinson (2014) Functional suppression of HAMP domain signaling defects in the E. coli serine chemoreceptor. J. Mol. Biol. 426: 3642-3655. (PDF)
Pedetta, A., J.S. Parkinson and C.A. Studdert (2014) Signalling-dependent interactions between the kinase-coupling protein CheW and chemoreceptors in living cells. Mol. Microbiol. 93: 1144-1155. (PDF)
Han, X.S. and J.S. Parkinson (2014) An unorthodox sensory adaptation site in the Escherichia coli serine chemoreceptor. J. Bacteriol. 196: 641-649. (PDF)
Nishiyama, S., A. Garzon and J.S. Parkinson (2014) Mutational analysis of the P1 phosphorylation domain in Escherichia coli CheA, the signaling kinase for chemotaxis. J. Bacteriol. 196: 257-264. (PDF)
Ames, P., Q. Zhou and J.S. Parkinson (2014) HAMP domain structural determinants for signalling and sensory adaptation in Tsr, the Escherichia coli serine chemoreceptor. Mol. Microbiol. 91: 875-886. (PDF)
Ortega, D.R., C. Yang, P. Ames, J. Baudry, J.S. Parkinson and I.B. Zhulin (2013) A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors. Nat. Commun. 4: 2881. (PDF)
Briegel, A., P. Ames, J.C. Gumbart, C.M. Oikonomou, J.S. Parkinson and G.T. Jensen (2013) The mobility of two kinase domains in the Escherichia coli chemoreceptor array varies with signalling state. Mol. Microbiol. 89: 831-841. (PDF)
Kitanovic, S., P. Ames and J. S. Parkinson (2011) Mutational analysis of the control cable that mediates transmembrane signaling in the E. coli serine chemoreceptor. J. Bacteriol. 193: 5062-5072. (PDF)
Pham, H.T and J S. Parkinson (2011) Phenol sensing by E. coli chemoreceptors: A non-classical mechanism. J. Bacteriol. 193: 6597-6604. (PDF)
Gosink, K. K., Y. Zhao and J S. Parkinson (2011) Mutational analysis of N381, a key trimer contact residue in Tsr, the E. coli serine chemoreceptor. J. Bacteriol. 193: 6452-6460. (PDF)
Massazza, D.A., J.S. Parkinson and C.A. Studdert (2011) Cross- linking evidence for motional constraints within chemoreceptor
trimers of dimers. Biochemistry 50: 820-827. (PDF)
Zhou, Q., P. Ames and J.S. Parkinson (2011) Biphasic control logic of HAMP domain signalling in the E. coli serine chemoreceptor. Mol. Microbiol. 80: 596-611. (PDF)
Cardozo, M.J., D.A. Massazza, J.S. Parkinson and C.A. Studdert (2010) Disruption of chemoreceptor signaling arrays by high levels of CheW, the receptor-kinase coupling protein. Mol. Microbiol. 75: 1171-1181. (pdf)
Zhou, Q., P. Ames and J.S. Parkinson (2009) Mutational analyses of HAMP helices suggest a dynamic bundle model of input-output signalling in chemoreceptors. Mol. Microbiol. 73: 801-814. (pdf)
Ames, P., Q. Zhou and J. S. Parkinson (2008) Mutational analysis of the connector segment in the HAMP domain of Tsr, the Escherichia coli serine chemoreceptor. J. Bacteriol. 190 :6676-85. (pdf)
Mowery, P., J.B. Ostler and J.S. Parkinson (2008) Different signaling roles of two conserved residues in the cytoplasmic hairpin tip of Tsr, the E. coli serine chemoreceptor. J. Bacteriol. 190: 8065-74. (pdf)
Ames, P. and J.S. Parkinson (2007) Phenotypic suppression methods for analyzing intra-and inter-molecular signaling interactions of chemoreceptors. Methods in Enzymology 423: 436-457. (pdf)
Parkinson, J.S. (2007) A "bucket of light" for viewing bacterial colonies in soft agar. Methods in Enzymology 423: 432-435. (pdf)
Studdert, C.A. and J.S. Parkinson (2007) In vivo crosslinking methods for analyzing the assembly and architecture of chemoreceptor arrays. Methods in Enzymology 423: 414-431. (pdf)
Ames, P. and J.S. Parkinson (2006) Conformational suppression of inter-receptor signaling defects. Proc. Natl. Acad. Sci. USA 102: 9292-9297. (pdf)
Burón-Barral, M., K.K. Gosink and J.S. Parkinson (2006) Loss- and gain-of-function mutations in the F1-HAMP region of the Escherichia coli aerotaxis transducer Aer. J. Bacteriol. 188: 3477-3486. (pdf)
Gosink, K.K., M. Burón-Barral and J.S. Parkinson (2006) Signaling interactions between the aerotaxis transducer Aer and heterologous chemoreceptors in E. coli. J. Bacteriol. 188: 3487-3493. (pdf)
Wright, S., B. Walia, J.S. Parkinson and S. Khan. (2006) Differential activation of Escherichia coli chemoreceptors by blue-light stimuli. J. Bacteriol. 188: 3962-3971. (pdf)
Zhao, J. and J.S. Parkinson (2006) Cysteine-scanning analysis of the chemoreceptor-coupling domain of the Escherichia coli chemotaxis signaling kinase CheA. J. Bacteriol. 188: 4321-4330. (pdf)
Zhao, J. and J.S. Parkinson (2006) Mutational analysis of the chemoreceptor-coupling domain of the Escherichia coli chemotaxis signaling kinase CheA. J. Bacteriol. 188: 3299-3307. (pdf)
Studdert, C.A. and J.S. Parkinson (2005) Insights into the organization and dynamics of bacterial chemoreceptor clusters through in vivo crosslinking studies. Proc. Natl. Acad. Sci. USA 102: 15623-15628. (pdf)
Bibikov, S.I., A.C. Miller, K.K. Gosink and J.S. Parkinson (2004) Methylation-independent aerotaxis mediated by the Escherichia coli Aer protein. J. Bacteriol. 186: 3730-3737. (pdf)
Jahreis, K., T.B. Morriso, A. Garzon and J.S. Parkinson (2004) Chemotactic signaling by an Escherichia coli CheA mutant that lacks the binding domain for phosphoacceptor partners. J. Bacteriol. 186: 2664-2672. (pdf)
Studdert, C.A. and J.S. Parkinson (2004) Crosslinking snapshots of bacterial chemoreceptor squads. Proc. Natl. Acad. Sci. USA 101: 2117-2122. (pdf)
Ames, P., C. A. Studdert, R.H. Reiser and J.S. Parkinson (2002) Collaborative signaling by mixed chemoreceptor teams in Escherichia coli. Proc. Natl. Acad. Sci. USA 99: 7060-7065. (pdf)
Bibikov S.I., L.A. Barnes, Y. Gitin, and J.S. Parkinson (2000) Domain organization and FAD-binding determinants in the aerotaxis signal transducer Aer of Escherichia coli. Proc. Natl. Acad. Sci. USA 97: 5830-5835. (pdf)
Cho, H. S., S. Y. Lee, D. Yan, X. Pan, J. S. Parkinson, S. Kustu, D. E. Wemmer and J. G. Pelton (2000). NMR Structure of Activated CheY. J. Mol. Biol. 297: 543-551. (pdf)
Stewart, R. C., K. Jahreis and J. S. Parkinson (2000) Rapid phosphotransfer to CheY from a CheA protein lacking the CheY-binding domain. Biochemistry 39: 13157-13165. (pdf)
Bibikov, S. I., R. Biran, K. E. Rudd and J. S. Parkinson (1997) A signal transducer for aerotaxis in Escherichia coli. J. Bacteriol. 179: 4075-4079. (pdf)
Morrison, T.B. and J.S. Parkinson (1997) A fragment liberated from the Escherichia coli CheA kinase that blocks stimulatory, but not inhibitory, chemoreceptor signaling. J. Bacteriol. 179: 5543-5550. (pdf)
Spiro, P.A., J.S. Parkinson, and H.G. Othmer (1997) A model of excitation and adaptation in bacterial chemotaxis. Proc. Natl. Acad. Sci. USA 94: 7263-7268. (pdf)
Ames, P., Y.A. Yu and J.S. Parkinson (1996) Methylation segments are not required for chemotactic signaling by cytoplasmic fragments of Tsr, the methyl-accepting serine chemoreceptor of Escherichia coli. Mol. Microbiol. 9: 737-746. (pdf)
Garzón, A. and J.S. Parkinson (1996) Chemotactic signaling by the P1 phosphorylation domain liberated from the CheA histidine kinase of Escherichia coli. J. Bacteriol. 178: 6752-6758. (pdf)
Lux, R., K. Jahreis, K. Bettenbrook, J.S. Parkinson and J.W. Lengeler (1995) Coupling the phosphotransferase system and the methyl-accepting chemotaxis protein-dependent chemotaxis signaling pathways of Escherichia coli. Proc. Natl. Acad. Sci. USA 92: 11583-11587. (pdf)
Sanatinia, H, E.C. Kofoid, T.B. Morrison and J.S. Parkinson (1995) The smaller of two overlapping cheA gene products is not essential for chemotaxis in Escherichia coli. J. Bacteriol. 177: 2713-2720. (pdf)
Ames, P. and J.S. Parkinson (1994) Constitutively signaling fragments of Tsr, the E. coli serine chemoreceptor. J. Bacteriol. 176: 6340-6348. (pdf)
Morrison, T.B. and J.S. Parkinson (1994) Liberation of an interaction domain from the phosphotransfer region of CheA, a signaling kinase of E. coli. Proc. Natl. Acad. Sci. USA 91: 5485-89. (pdf)
Kofoid, E.C. and J.S. Parkinson (1991) Tandem translation starts in the cheA locus of Escherichia coli. J. Bacteriol. 173: 2116-2119. (pdf)
Liu, J. and J. S. Parkinson (1991) Genetic evidence for interaction between the CheW and Tsr proteins during chemoreceptor signaling by Escherichia coli. J. Bacteriol. 173: 4941-4951. (pdf)
Liu, J. and J.S. Parkinson (1989) Role of CheW protein in coupling membrane receptors to the intracellular signaling system of bacterial chemotaxis. Proc. Natl. Acad. Sci. USA 86: 8703-8707. (pdf)
Ames, P. and J.S. Parkinson (1988) Transmembrane signaling by bacterial chemoreceptors: Escherichia coli transducers with locked signal output. Cell 55: 817-826. (pdf)
Chun, S.Y. and J.S. Parkinson (1988) Bacterial motility: Membrane topology of the Escherichia coli MotB protein. Science 239:276-278. (pdf)
Kofoid, E. and J.S. Parkinson (1988) Transmitter and receiver modules in bacterial signaling proteins. Proc. Natl. Acad. Sci. USA 85: 4981-4985. (pdf)
Wolff, C. and J.S. Parkinson (1988) Aspartate taxis mutants of the Escherichia coli Tar chemoreceptor. J. Bacteriol. 170: 4509-4515. (pdf)
Callahan, A.M., B.L. Frazier and J.S. Parkinson (1987) Chemotaxis in E. coli: Construction and properties of λtsr transducing phage. J. Bacteriol. 169: 1246-1253. (pdf)
Slocum, M.K., N.F. Halden and J.S. Parkinson (1987) Hybrid Escherichia coli sensory transducers with altered stimulus detection and signaling properties. J. Bacteriol. 169: 2938-2944. (pdf)
Callahan, A.M. and J.S. Parkinson (1985) Genetics of methyl-accepting chemotaxis proteins in Escherichia coli: cheD mutations affect the structure and function of the Tsr transducer. J. Bacteriol. 161: 96-104. (pdf)
Slocum, M.K. and J.S. Parkinson (1985) Genetics of methyl-accepting chemotaxis proteins in Escherichia coli: Null phenotypes of the tar and tap genes. J. Bacteriol. 163: 586-594. (pdf)
Parkinson, J.S., S.R. Parker, P.B. Talbert and S.E. Houts (1983) Interactions between chemotaxis genes and flagellar genes in Escherichia coli. J. Bacteriol. 155: 265-274. (pdf)
Slocum, M.K. and J.S. Parkinson (1983) Genetics of methyl-accepting chemotaxis proteins in Escherichia coli: organization of the tar region. J. Bacteriol. 155: 565-577. (pdf)
Yonekawa, H., H. Hayashi, H. and J.S. Parkinson (1983) Requirement of the cheB function for sensory adaptation in Escherichia coli. J. Bacteriol. 156: 1228-1235. (pdf)
Parkinson, J.S. and S.E. Houts (1982) Isolation and behavior of Escherichia coli deletion mutants lacking chemotaxis functions. J. Bacteriol. 151 :106-113. (pdf)
Sherris, D. and J.S. Parkinson (1981) Post-translational processing of methyl-accepting chemotaxis proteins in Escherichia coli. Proc. Natl. Acad. Sci. USA 78: 6051-6055. (pdf)
Parkinson, J.S. (1980) Novel mutations affecting a signaling component for chemotaxis in Escherichia coli. J. Bacteriol. 142: 953-961. (pdf)
Smith, R.A. and J.S. Parkinson (1980) Overlapping genes at the cheA locus of Escherichia coli. Proc. Natl. Acad. Sci. USA 77 :5370-74. (pdf)
DeFranco, A., Parkinson, J.S. and D.E. Koshland (1979) Functional homology of chemotaxis genes in Escherichia coli and Salmonella typhimurium. J. Bacteriol. 139: 107-114. (pdf)
Parkinson, J.S. and S.R. Parker (1979) Interaction of the cheC and cheZ gene products is required for chemotactic behavior in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 76: 2390-2394. (pdf)
Parkinson, J.S. (1978) Complementation analysis and deletion mapping of Escherichia coli mutants defective in chemotaxis. J. Bacteriol. 135: 45-53. (pdf)
Parkinson, J.S. and P.T. Revello (1978) Sensory adaptation mutants of Escherichia coli. Cell 15: 1221-1230. (pdf)
Parkinson, J.S. (1976) cheA, cheB, and cheC genes in Escherichia coli and their role in chemotaxis, J. Bacteriol. 126: 758-770. (pdf)
Parkinson, J.S. (1974) Data processing by the chemotaxis machinery of Escherichia coli. Nature 252: 317.
Davis, R.W. and J.S. Parkinson (1971) Deletion mutants of bacteriophage lambda. III. Physical structure of attφ. J. Mol. Biol. 56:403.
Parkinson, J.S. (1971) Deletion mutants of bacteriophage lambda. II. Genetic properties of att-defective mutants. J. Mol. Biol. 56:385.
Parkinson, J.S. and R.J. Huskey (1971) Deletion mutants of bacteriophage lambda. I. Isolation and initial characterization. J. Mol. Biol. 56: 369.
Parkinson, J.S. and R.W. Davis (1971) A physical map of the left arm of the lambda chromosome. J. Mol. Biol. 56: 425.
Parkinson, J.S. (1968) Genetics of the left arm of the chromosome of bacteriophage lambda. Genetics 59: 311.
Parkinson, J.S. (2016) Classic spotlight: The discovery of bacterial transduction. J. Bacteriol. 198: 2899-2900. (pdf)
Lai, R.Z. & J.S. Parkinson (2018) Monitoring two-component sensor kinases with a chemotaxis signal readout. Methods in Molecular Biology: Bacterial Chemosensing, Springer.
Ames, P. & J.S. Parkinson (2018) All-codon mutagenesis for structure-function studies of chemotaxis signaling proteins. Methods in Molecular Biology: Bacterial Chemosensing, Springer.
Parkinson, J.S. (2016) Classic Spotlight: Dawn of the Molecular Era of Bacterial Chemotaxis J. Bacteriology 198: 1796 (pdf)
Parkinson, J.S. (2016) Classic Spotlight: Look, Max—No Math Required! J. Bacteriology 198: 2281 (pdf)
Parkinson, J.S., G L. Hazelbauer and J.J. Falke (2015) Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Trends Microbiol. 23: 257-266. (pdf)
Boos, W., J.S. Parkinson, U. Jenal, J. Vogel and L. Sogaard-Andersen (2013) Alexander Böhm (1971-2012). Mol. Microbiol. 88: 219-221. (pdf)
Parkinson, J.S. (2010) Signaling mechanisms of HAMP domains in chemoreceptors and sensor kinases. Annu. Rev. Microbiol. 64: 101-122. (pdf)
Hazelbauer, G.L., J.J.Falke and J.S. Parkinson (2008) Bacterial chemoreceptors: high-performance signaling in networked arrays. Trends in Biochemical Sciences 33: 9-19. (pdf)
Parkinson, J.S. (2007) Ancient chemoreceptors retain their flexibility (commentary). Proc. Natl. Acad. Sci. USA 104: 2559-2560. (pdf)
Parkinson, J. S., Ames, P., and Studdert, C. A. (2005) Collaborative signaling by bacterial chemoreceptors. Curr Opin Microbiol 8:116-121. (pdf)
Parkinson, J.S. (2004) Signal amplification in bacterial chemotaxis through receptor teamwork. ASM News 70: 575-582. (pdf)
Parkinson, J. S. (2003) Bacterial chemotaxis: A new player in response regulator dephosphorylation (commentary). J. Bacteriol. 185: 1492-4. (pdf)
Appleby, J., J. S. Parkinson, and R. B. Bourret (1996) Signal transduction by the multi-step phosphorelay: Not necessarily a road less traveled. Cell 86: 1-4. (pdf)
Parkinson, J.S. (1995) Genetic approaches for signaling pathways and proteins. In: Two-Component Signal Transduction, J.A. Hoch and T.J. Silhavy (eds.), ASM Press, Washington, D.C. (pdf)
Parkinson, J.S. (1993) Signal transduction schemes of bacteria. Cell 73: 857-871. (pdf)
Parkinson, J.S. and D.F. Blair (1993) Does E. coli have a nose? Science 259: 1701-1702. (pdf)
Parkinson, J.S. and E.C. Kofoid (1992) Communication modules in bacterial signaling proteins. Ann. Rev. Genetics 26: 71-112. (pdf)
Macnab, R.M. and J.S. Parkinson (1991) Genetic analysis of the bacterial flagellum. Trends in Genetics 7: 196-200.
Parkinson, J.S. (1990) Communication modules in bacterial signaling proteins. ASM News 56: 197-201.
Parkinson, J.S. (1989) Molecular genetics of sensory signaling in bacterial chemotaxis. In: Genetic Variation in Chemical Sensing Systems. C. Wysocki and M. Kare (eds.), Marcel Dekker, New York.
Ames, P., J. Chen, C. Wolff and J.S. Parkinson (1988) Structure-function studies of bacterial chemosensors. Cold Spring Harbor Symp. Quant. Biol. 53: 59-65.
Parkinson, J.S. (1988) Protein phosphorylation in bacterial chemotaxis. Cell 53: 1-2.
Parkinson, J.S. (1987) Doing behavioral genetics with bacteria. Genetics 116: 499-500.
Parkinson, J.S., A.M. Callahan and M.K. Slocum (1984) Genetics of sensory transducers in Escherichia coli. Taniguchi Symposia on Brain Sciences (F. Oosawa et al., eds.) 7: 147-160, Japan Scientific Societies Press, Tokyo.
Parkinson, J.S. and G.L. Hazelbauer (1983) Bacterial chemotaxis: Molecular genetics of sensory transduction and chemotactic gene expression. In: Gene Function in Prokaryotes, Cold Spring Harbor Laboratory, New York.
Parkinson, J.S., M.K. Slocum, A.M. Callahan, D. Sherris and S.E. Houts (1983) Genetics of transmembrane signaling proteins in E. coli. In: Mobility and Recognition in Cell Biology. H. Sund and C. Veeger (eds.), Walter de Gruyter, Berlin, pp. 563-577.
Parkinson, J.S. (1981) Genetics of Bacterial Chemotaxis. In: Symposia of the Society for General Microbiology. XXXI - Genetics as a Tool in Microbiology. pp. 265-290.
Hazelbauer, G.L. and J.S. Parkinson (1977) Bacterial Chemotaxis. In: Receptors and Recognition: Microbial Interactions, J. Riessig (ed.), Chapman and Hall, London.
Parkinson, J.S. (1977) Behavioral genetics in bacteria. Ann. Rev. Genetics 11: 397-414.
Parkinson, J.S. (1975) Genetics of chemotactic behavior in bacteria. Cell 4: 183.